![]() ![]() Further, more detailed studies, with larger narcolepsy patient groups, are required in the future. For this reason, the generalizability of the results is limited. First, the sample size was small, and thus, we could not subdivide narcolepsy patients into two types (narcolepsy with cataplexy and without cataplexy). In the control group, theta activities in the second, third, and fourth NREM period were significantly higher than those of the first NREM period (p<0.05) ( Table 2). In the narcolepsy group, theta activities in the second and third NREM periods were significantly higher than those of the first NREM period. Meanwhile, in the control group, delta activities in the second, third, and fourth NREM period were significantly lower than those of the first NREM period (p<0.05). In the narcolepsy group, delta wave activities in the second and third NREM periods were significantly lower than those of the first NREM period. Next, we compared the difference of delta and theta activity by sleep period in each group. ![]() For the third and fourth NREM sleep periods, no difference was seen in the delta and theta power between the two groups. For the second NREM sleep period, theta power in the narcolepsy group (0.18☐.01) was significantly higher than the control group (0.13☐.00) (p<0.05). On the other hand, the theta power of the narcolepsy group (0.15☐.01) was significantly higher than that of the control group (0.10☐.01) (p<0.05). In comparison of the delta power of the first NREM period, the power in the narcolepsy group (0.76☐.02) was significantly lower than the control group (0.83☐.01) (p<0.05). 4 5įirst, we compared the total powers of delta and theta activity of two groups. However, PSG alone cannot provide detailed pathophysiological information about specific sleep disorders. 3 PSG not only makes it possible to identify the macroscopic structures of sleep such as sleep stages and SOREMPs, but also enables behavior and movement to be monitored during sleep. 3 The international classification of sleep disorders, second edition (ICSD-II) provides the following diagnostic criteria for narcolepsy: sleep latency of less than 8 minutes, two or more sleep-onset REM periods (SOREMPs) seen on MSLT following sufficient nocturnal sleep (minimum 6 hours) during the night prior to testing. 1 2 Narcolepsy is diagnosed by clinical history taking, polysomnography (PSG), multiple sleep latency test (MSLT), and hypocretin (Hcrt) levels in the cerebrospinal fluid. Narcolepsy is a chronic neurological sleep disorder of rapid eye movement (REM) sleep, non-REM (NREM) sleep, and of the sleep-wake cycle, characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), sleep paralysis, hypnagogic hallucinations, and disturbed night sleep.
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